2vis | pdb_00002vis
INFLUENZA VIRUS HEMAGGLUTININ, (ESCAPE) MUTANT WITH THR 131 REPLACED BY ILE, COMPLEXED WITH A NEUTRALIZING ANTIBODY
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Overview
The structure of the hemagglutinin (HA) of a mutant influenza virus that, escapes neutralization by a monoclonal antibody shows that the mutation, causes changes in HA structure which avoid an energetically less favorable, conformation. However, the structure of the mutant HA.Fab complex, indicates that the antibody binds selectively to mutant HA in a wild, type-like distorted conformation. The association of an antibody with a, less favored HA conformation represents an alternative to previously, described mechanisms of escape from neutralization by antibodies.
About this Structure
2VIS is a Protein complex structure of sequences from Mus musculus and Unidentified influenza virus with NAG and ZN as ligands. Full crystallographic information is available from OCA.
Reference
Antigen distortion allows influenza virus to escape neutralization., Fleury D, Wharton SA, Skehel JJ, Knossow M, Bizebard T, Nat Struct Biol. 1998 Feb;5(2):119-23. PMID:9461077
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