2uvx | pdb_00002uvx
STRUCTURE OF PKA-PKB CHIMERA COMPLEXED WITH 7-AZAINDOLE
Overview
6-phenylpurines were identified as novel, ATP-competitive inhibitors of protein kinase B (PKB/Akt) from a fragment-based screen and were rapidly progressed to potent compounds using iterative protein-ligand crystallography with a PKA-PKB chimeric protein. An elaborated lead compound showed cell growth inhibition and effects on cellular signaling pathways characteristic of PKB inhibition.
About this Structure
2UVX is a Protein complex structure of sequences from Bos taurus. Full crystallographic information is available from OCA.
Reference
Rapid evolution of 6-phenylpurine inhibitors of protein kinase B through structure-based design., Donald A, McHardy T, Rowlands MG, Hunter LJ, Davies TG, Berdini V, Boyle RG, Aherne GW, Garrett MD, Collins I, J Med Chem. 2007 May 17;50(10):2289-92. Epub 2007 Apr 24. PMID:17451235 Page seeded by OCA on Thu May 22 22:30:05 2008
Proteopedia Page Contributors and Editors (what is this?)
- Pages with broken file links
- Bos taurus
- Protein complex
- Aherne, G W.
- Boyle, R G.
- Collins, I.
- Davies, T G.
- Donald, A.
- Garrett, M D.
- Hunter, L J.
- Mchardy, T.
- Rowlands, M G.
- Atp- binding
- Camp
- Kinase
- Lipoprotein
- Myristate
- Nuclear protein
- Nucleotide-binding
- Phosphorylation
- Protein kinase inhibitor
- Serine/threonine-protein kinase
- Transferase
- Transferase/inhibitor complex
