1ffx | pdb_00001ffx
TUBULIN:STATHMIN-LIKE DOMAIN COMPLEX
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Overview
Phosphoproteins of the stathmin family interact with the alphabeta tubulin, heterodimer (tubulin) and hence interfere with microtubule dynamics. The, structure of the complex of GDP-tubulin with the stathmin-like domain of, the neural protein RB3 reveals a head-to-tail assembly of two tubulins, with a 91-residue RB3 alpha helix in which each copy of an internal, duplicated sequence interacts with a different tubulin. As a result of the, relative orientations adopted by tubulins and by their alpha and beta, subunits, the tubulin:RB3 complex forms a curved structure. The RB3 helix, thus most likely prevents incorporation of tubulin into microtubules by, holding it in an assembly with a curvature very similar to that of the, depolymerization products of microtubules.
About this Structure
1FFX is a Protein complex structure of sequences from Bos taurus and Rattus norvegicus with GTP and GDP as ligands. Full crystallographic information is available from OCA.
Reference
The 4 A X-ray structure of a tubulin:stathmin-like domain complex., Gigant B, Curmi PA, Martin-Barbey C, Charbaut E, Lachkar S, Lebeau L, Siavoshian S, Sobel A, Knossow M, Cell. 2000 Sep 15;102(6):809-16. PMID:11030624
Page seeded by OCA on Tue Nov 20 14:53:54 2007
