2c0o | pdb_00002c0o

SRC FAMILY KINASE HCK WITH BOUND INHIBITOR A-770041

File:2c0o.gif

spinqualitylabelsall models 2c0o, resolution 2.85Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D

Overview

We describe the identification, SAR, and pharmacology of the src-family, selective lck inhibitor A-770041 that prolongs the survival of major, histocompatibility mismatched allografts in models of solid organ, transplant rejection for greater than 65 days.

About this Structure

2C0O is a [Single protein] structure of sequence from [Homo sapiens] with CA and L2G as [ligands]. Active as [[1]], with EC number [2.7.1.112]. Full crystallographic information is available from [OCA].

Reference

Discovery of A-770041, a src-family selective orally active lck inhibitor that prevents organ allograft rejection., Burchat A, Borhani DW, Calderwood DJ, Hirst GC, Li B, Stachlewitz RF, Bioorg Med Chem Lett. 2006 Jan 1;16(1):118-22. Epub 2005 Oct 10. PMID:16216497

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