1if1 | pdb_00001if1
INTERFERON REGULATORY FACTOR 1 (IRF-1) COMPLEX WITH DNA
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Overview
The family of interferon regulatory factor (IRF) transcription factors is, important in the regulation of interferons in response to infection by, virus and in the regulation of interferon-inducible genes. The IRF family, is characterized by a unique 'tryptophan cluster' DNA-binding region. Here, we report the crystal structure of the IRF-1 region bound to the natural, positive regulatory domain I (PRD I) DNA element from the interferon-beta, promoter. The structure provides the first three-dimensional view of a, member of the growing IRF family, revealing a new helix-turn-helix motif, that latches onto DNA through three of the five conserved tryptophans. The, motif selects a short GAAA core sequence through an obliquely angled, recognition helix, with an accompanying bending of the DNA axis in the, direction of the protein. Together, these features suggest a basis for the, occurrence of GAAA repeats within IRF response elements and provide clues, to the assembly of the higher-order interferon-beta enhancesome.
About this Structure
1IF1 is a Single protein structure of sequence from Mus musculus. Full crystallographic information is available from OCA.
Reference
Structure of IRF-1 with bound DNA reveals determinants of interferon regulation., Escalante CR, Yie J, Thanos D, Aggarwal AK, Nature. 1998 Jan 1;391(6662):103-6. PMID:9422515
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