SelB

Molecular Recognition in SelB Elongation factor SelB uses several methods to recognize the selenocysteine insertion sequence found in messenger RNA. The insertion sequence forms a hairpin loop with an unstacked guanine base in the loop. This guanine forms specific hydrogen bonds with the protein and with two bridging water molecules (shown in cyan in the jmol). The planar base is also sandwiched between three amino acidsin the protein, which form a tight hydrophobic pocket. This is best seen using a spacefilling diagram. The overall shape of the hairpin is recognized by contacts with several arginine and lysine amino acids. In particular, notice the intimate contact formed by both the charged nitrogen and hydrophobic carbon chain of arginine 606.

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