1jnp | pdb_00001jnp
Crystal Structure of Murine Tcl1 at 2.5 Resolution
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Overview
Tcl1 and Mtcp1, members of the Tcl1 family, are implicated in T-cell, prolymphocytic leukemia. The crystal structure of a dimer of murine Tcl1, has been determined at 2.5 A resolution with an R factor of 0.225. Murine, Tcl1, human Tcl1 and Mtcp1 share very similar subunit structures, with RMS, differences of 0.6 and 1.4 A for C(alpha) atoms, respectively, while the, sequences share 50 and 36% identity, respectively. These structures fold, into an eight-stranded beta-barrel of unique topology and high internal, symmetry of 1.1-1.3 A for the two halves of human and murine Tcl1 and 1.7, A for Mtcp1, despite the low 12-13% sequence identity. The molecular, surfaces of all three structures showed a common planar region which is, likely to be involved in protein-protein interactions.
About this Structure
1JNP is a Single protein structure of sequence from Mus musculus. Full crystallographic information is available from OCA.
Reference
Structure of murine Tcl1 at 2.5 A resolution and implications for the TCL oncogene family., Petock JM, Torshin IY, Wang YF, Du Bois GC, Croce CM, Harrison RW, Weber IT, Acta Crystallogr D Biol Crystallogr. 2001 Nov;57(Pt 11):1545-51. Epub 2001, Oct 25. PMID:11679718
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