1k3v | pdb_00001k3v
Porcine Parvovirus Capsid
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Overview
The structure of baculovirus-expressed porcine parvovirus (PPV) capsids, was solved using X-ray crystallography and was found to be similar to the, related canine parvovirus (CPV) and minute virus of mice (MVM). The PPV, capsid protein has 57 % and 49 % amino acid sequence identity with CPV and, MVM, respectively, but the degree of conservation of surface-exposed, residues is lower than average. Consequently, most of the structural, differences are on the surface and are the probable cause of the known, variability in antigenicity and host range. The NADL-2 and Kresse strains, of PPV have distinct tissue tropisms and pathogenicity, which are mediated, by one or more of the amino acid residues 381, 386, and 436. These, residues are on or near the surface of the virus capsid, where they are, likely to be associated with virus-cell interactions.
About this Structure
1K3V is a Single protein structure of sequence from Porcine parvovirus. Full crystallographic information is available from OCA.
Reference
The structure of porcine parvovirus: comparison with related viruses., Simpson AA, Hebert B, Sullivan GM, Parrish CR, Zadori Z, Tijssen P, Rossmann MG, J Mol Biol. 2002 Feb 1;315(5):1189-98. PMID:11827486
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