1kw4 | pdb_00001kw4
Polyhomeotic SAM domain structure
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Overview
The polycomb group (PcG) proteins are important in the maintenance of, stable repression patterns during development. Several PcG members contain, a protein protein interaction module called a SAM domain (also known as, SPM, PNT and HLH). Here we report the high-resolution structure of the SAM, domain of polyhomeotic (Ph). Ph-SAM forms a helical polymer structure, providing a likely mechanism for the extension of PcG complexes. The, structure of the polymer resembles that formed by the SAM domain of, another transcriptional repressor, TEL. The formation of these polymer, structures by SAM domains in two divergent repressors suggests a conserved, mode of repression involving a higher order chromatin structure.
About this Structure
1KW4 is a Single protein structure of sequence from Drosophila melanogaster. Full crystallographic information is available from OCA.
Reference
The SAM domain of polyhomeotic forms a helical polymer., Kim CA, Gingery M, Pilpa RM, Bowie JU, Nat Struct Biol. 2002 Jun;9(6):453-7. PMID:11992127
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