2q11 | pdb_00002q11

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Template:STRUCTURE 2q11

File:2q11.png

Structure of BACE complexed to compound 1

Template:ABSTRACT PUBMED 17685503

About this Structure

2Q11 is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

2-Amino-3,4-dihydroquinazolines as inhibitors of BACE-1 (beta-site APP cleaving enzyme): Use of structure based design to convert a micromolar hit into a nanomolar lead., Baxter EW, Conway KA, Kennis L, Bischoff F, Mercken MH, Winter HL, Reynolds CH, Tounge BA, Luo C, Scott MK, Huang Y, Braeken M, Pieters SM, Berthelot DJ, Masure S, Bruinzeel WD, Jordan AD, Parker MH, Boyd RE, Qu J, Alexander RS, Brenneman DE, Reitz AB, J Med Chem. 2007 Sep 6;50(18):4261-4. Epub 2007 Aug 8. PMID:17685503

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