1nsw | pdb_00001nsw
The Crystal Structure of the K18G Mutant of the thioredoxin from Alicyclobacillus acidocaldarius
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Overview
We report a crystallographic and computational analysis of two mutant, forms of the Alicyclobacillus acidocaldarius thioredoxin (BacTrx) done in, order to evaluate the contribution of two specific amino acids to the, thermostability of BacTrx. Our results suggest that the thermostability of, BacTrx may be modulated by mutations affecting the overall electrostatic, energy of the protein.
About this Structure
1NSW is a Single protein structure of sequence from Alicyclobacillus acidocaldarius. Active as Thioredoxin-disulfide reductase, with EC number 1.8.1.9 Full crystallographic information is available from OCA.
Reference
An integrated structural and computational study of the thermostability of two thioredoxin mutants from Alicyclobacillus acidocaldarius., Bartolucci S, De Simone G, Galdiero S, Improta R, Menchise V, Pedone C, Pedone E, Saviano M, J Bacteriol. 2003 Jul;185(14):4285-9. PMID:12837806
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