1oun | pdb_00001oun
CRYSTAL STRUCTURE OF NUCLEAR TRANSPORT FACTOR 2 (NTF2)
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Overview
Nuclear transport factor 2 (NTF2) facilitates protein transport into the, nucleus and interacts with both the small Ras-like GTPase Ran and, nucleoporin p62. We have determined the structure of bacterially expressed, rat NTF2 at 1.6 angstroms resolution using X-ray crystallography. The NTF2, polypeptide chain forms an alpha + beta barrel that opens at one end to, form a distinctive hydrophobic cavity and its fold is homologous to that, of scytalone dehydratase. The NTF2 hydrophobic cavity is a candidate for a, potential binding site for other proteins involved in nuclear import such, as Ran and nucleoporin p62. In addition, the hydrophobic cavity contains a, putative catalytic Asp-His pair, which raises the possibility of an, unanticipated enzymatic activity of the molecule that may have, implications for the molecular mechanism of nuclear protein import.
About this Structure
1OUN is a Single protein structure of sequence from Rattus norvegicus. Full crystallographic information is available from OCA.
Reference
The 1.6 angstroms resolution crystal structure of nuclear transport factor 2 (NTF2)., Bullock TL, Clarkson WD, Kent HM, Stewart M, J Mol Biol. 1996 Jul 19;260(3):422-31. PMID:8757804
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