2nvk

File:2nvk.png

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2nvk, resolution 2.40Å (default scene)
Ligands:	FAD, NAP
Gene:	Trxr-1 (Drosophila melanogaster)
Activity:	Thioredoxin-disulfide reductase, with EC number 1.8.1.9
Structural annotation: Resources: InterPro : Ipr001327, Ipr000815, Ipr012999, Ipr004099, Ipr013027, Ipr006338, Ipr001100 Pfam : PF02852, PF00070, PF07992 UniProt : P91938
Functional annotation: Cellular component: mitochondrion cytoplasm Biological process: thioredoxin pathway cell redox homeostasis electron transport determination of adult life span Molecular function: oxidoreductase activity, acting on NADH or NADPH, disulfide as acceptor thioredoxin-disulfide reductase activity FAD binding oxidoreductase activity antioxidant activity protein binding NADP binding glutathione-disulfide reductase activity
Evolutionary conservation: Toggle Conservation Colors: Rows = identical sequences: Further Information: Caveats, Explanation, Complete Results at ConSurfDB
Resources:	FirstGlance, OCA, RCSB, PDBsum
Coordinates:	save as pdb, mmCIF, xml

About this Structure

2NVK is a Single protein structure of sequence from Drosophila melanogaster. Full crystallographic information is available from OCA.

Reference

Structural and biochemical studies reveal differences in the catalytic mechanisms of mammalian and Drosophila melanogaster thioredoxin reductases., Eckenroth BE, Rould MA, Hondal RJ, Everse SJ, Biochemistry. 2007 Apr 24;46(16):4694-705. Epub 2007 Mar 27. PMID:17385893

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