1pto | pdb_00001pto
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THE STRUCTURE OF A PERTUSSIS TOXIN-SUGAR COMPLEX AS A MODEL FOR RECEPTOR BINDING
Overview
Pertussis toxin is an exotoxin from the bacterium Bordetella pertussis, which is important the pathogenesis of whooping cough and the generation, of a protective immune response. The diverse biological activities of the, toxin depend on its ability to recognize carbohydrate-containing receptors, on a wide variety of eukaryotic cells. We present here the crystal, structure of pertussis toxin complexed with a soluble oligosaccharide from, transferrin. Binding sites for the terminal sialic acid-galactose moiety, are revealed on both subunits S2 and S3 of the B-oligomer. Identification, of amino acid residues involved in receptor binding will improve the, design of genetically inactivated toxins for use in new acellular whooping, cough vaccines.
About this Structure
1PTO is a Protein complex structure of sequences from Bordetella pertussis. Full crystallographic information is available from OCA.
Reference
Structure of a pertussis toxin-sugar complex as a model for receptor binding., Stein PE, Boodhoo A, Armstrong GD, Heerze LD, Cockle SA, Klein MH, Read RJ, Nat Struct Biol. 1994 Sep;1(9):591-6. PMID:7634099
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