2z8c | pdb_00002z8c
Phosphorylated insulin receptor tyrosine kinase in complex with (4-{[5-carbamoyl-4-(3-methylanilino)pyrimidin-2-yl]amino}phenyl)acetic acid
Disease
Known disease associated with this structure: Diabetes mellitus, insulin-resistant, with acanthosis nigricans OMIM:[147670], Hyperinsulinemic hypoglycemia, familial, 5 OMIM:[147670], Leprechaunism OMIM:[147670], Rabson-Mendenhall syndrome OMIM:[147670], Coronary artery disease, susceptibility to OMIM:[147545], Diabetes mellitus, noninsulin-dependent OMIM:[147545]
About this Structure
2Z8C is a Protein complex structure of sequences from Homo sapiens. Full crystallographic information is available from OCA.
Reference
Identification of a key element for hydrogen-bonding patterns between protein kinases and their inhibitors., Katayama N, Orita M, Yamaguchi T, Hisamichi H, Kuromitsu S, Kurihara H, Sakashita H, Matsumoto Y, Fujita S, Niimi T, Proteins. 2008 Sep 2;73(4):795-801. PMID:18767165
Page seeded by OCA on Wed Nov 12 20:15:32 2008
Proteopedia Page Contributors and Editors (what is this?)
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- Homo sapiens
- Protein complex
- Receptor protein-tyrosine kinase
- Katayama, N.
- Kurihara, H.
- Alternative splicing
- Atp-binding
- Carbohydrate metabolism
- Cleavage on pair of basic residue
- Diabetes mellitus
- Disease mutation
- Glycoprotein
- Kinase
- Membrane
- Nucleotide-binding
- Phosphorylation
- Polymorphism
- Receptor
- Transducer
- Transferase
- Transmembrane
- Tyrosine-protein kinase
