1ub4 | pdb_00001ub4
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crystal structure of MazEF complex
Overview
A structure of the Escherichia coli chromosomal MazE/MazF addiction module, has been determined at 1.7 A resolution. Addiction modules consist of, stable toxin and unstable antidote proteins that govern bacterial cell, death. MazE (antidote) and MazF (toxin) form a linear heterohexamer, composed of alternating toxin and antidote homodimers, (MazF(2)-MazE(2)-MazF(2)). The MazE homodimer contains a beta barrel from, which two extended C termini project, making interactions with flanking, MazF homodimers that resemble the plasmid-encoded toxins CcdB and Kid. The, MazE/MazF heterohexamer structure documents that the mechanism of, antidote-toxin recognition is common to both chromosomal and plasmid-borne, addiction modules, and provides general molecular insights into toxin, function, antidote degradation in the absence of toxin, and promoter DNA, binding by antidote/toxin complexes.
About this Structure
1UB4 is a Protein complex structure of sequences from Escherichia coli. Full crystallographic information is available from OCA.
Reference
Crystal structure of the MazE/MazF complex: molecular bases of antidote-toxin recognition., Kamada K, Hanaoka F, Burley SK, Mol Cell. 2003 Apr;11(4):875-84. PMID:12718874
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Proteopedia Page Contributors and Editors (what is this?)
- Pages with broken file links
- Escherichia coli
- Protein complex
- Burley, S.K.
- Hanaoka, F.
- Kamada, K.
- NYSGXRC, New.York.Structural.GenomiX.Research.Consortium.
- Addiction module
- Antidote
- New york structural genomix research consortium
- Nysgxrc
- Post-segregation
- Programmed cell death
- Protein structure initiative
- Psi
- Structural genomics
- Toxin
