1vsa | pdb_00001vsa
Crystal Structure of a 70S Ribosome-tRNA Complex Reveals Functional Interactions and Rearrangements. This file, 1VSA, contains the 50S ribosome subunit. 30S ribosome subunit is in the file 2OW8
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Overview
Our understanding of the mechanism of protein synthesis has undergone, rapid progress in recent years as a result of low-resolution X-ray and, cryo-EM structures of ribosome functional complexes and high-resolution, structures of ribosomal subunits and vacant ribosomes. Here, we present, the crystal structure of the Thermus thermophilus 70S ribosome containing, a model mRNA and two tRNAs at 3.7 A resolution. Many structural details of, the interactions between the ribosome, tRNA, and mRNA in the P and E sites, and the ways in which tRNA structure is distorted by its interactions with, the ribosome are seen. Differences between the conformations of vacant and, tRNA-bound 70S ribosomes suggest an induced fit of the ribosome structure, in response to tRNA binding, including significant changes in the, peptidyl-transferase catalytic site.
About this Structure
1VSA is a Protein complex structure of sequences from Thermus thermophilus. This structure superseeds the now removed PDB entry 1VS9. Full crystallographic information is available from OCA.
Reference
Crystal structure of a 70S ribosome-tRNA complex reveals functional interactions and rearrangements., Korostelev A, Trakhanov S, Laurberg M, Noller HF, Cell. 2006 Sep 22;126(6):1065-77. Epub 2006 Sep 7. PMID:16962654
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