3ekk | pdb_00003ekk
Insulin receptor kinase complexed with an inhibitor
Disease
Known disease associated with this structure: Diabetes mellitus, insulin-resistant, with acanthosis nigricans OMIM:[147670], Hyperinsulinemic hypoglycemia, familial, 5 OMIM:[147670], Leprechaunism OMIM:[147670], Rabson-Mendenhall syndrome OMIM:[147670]
About this Structure
3EKK is a 1 chain structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.
Reference
Discovery of 4,6-bis-anilino-1H-pyrrolo[2,3-d]pyrimidines: Potent inhibitors of the IGF-1R receptor tyrosine kinase., Chamberlain SD, Wilson JW, Deanda F, Patnaik S, Redman AM, Yang B, Shewchuk L, Sabbatini P, Leesnitzer MA, Groy A, Atkins C, Gerding R, Hassell AM, Lei H, Mook RA Jr, Moorthy G, Rowand JL, Stevens KL, Kumar R, Shotwell JB, Bioorg Med Chem Lett. 2008 Nov 18. PMID:19056263
Page seeded by OCA on Wed Jan 7 08:10:52 2009
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- Homo sapiens
- Receptor protein-tyrosine kinase
- Atkins, C.
- Chamberlain, S.
- Deanda, F.
- Dumble, M.
- Gerding, R.
- Groy, A.
- Korenchuk, S.
- Kumar, R.
- Lei, H.
- Mook, R.
- Moorthy, G.
- Redman, A.
- Rowland, J.
- Sabbatini, P.
- Shewchuk, L.
- Alternative splicing
- Atp-binding
- Carbohydrate metabolism
- Cleavage on pair of basic residue
- Diabetes mellitus
- Disease mutation
- Glycoprotein
- Insulin
- Kinase
- Membrane
- Nucleotide-binding
- Phosphoprotein
- Polymorphism
- Receptor
- Transferase
- Transmembrane
- Tyrosine kinase
- Tyrosine-protein kinase
