3ekn | pdb_00003ekn
Insulin receptor kinase complexed with an inhibitor
Disease
Known disease associated with this structure: Diabetes mellitus, insulin-resistant, with acanthosis nigricans OMIM:[147670], Hyperinsulinemic hypoglycemia, familial, 5 OMIM:[147670], Leprechaunism OMIM:[147670], Rabson-Mendenhall syndrome OMIM:[147670]
About this Structure
3EKN is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.
Reference
Optimization of 4,6-bis-anilino-1H-pyrrolo[2,3-d]pyrimidine IGF-1R tyrosine kinase inhibitors towards JNK selectivity., Chamberlain SD, Redman AM, Wilson JW, Deanda F, Shotwell JB, Gerding R, Lei H, Yang B, Stevens KL, Hassell AM, Shewchuk LM, Leesnitzer MA, Smith JL, Sabbatini P, Atkins C, Groy A, Rowand JL, Kumar R, Mook RA Jr, Moorthy G, Patnaik S, Bioorg Med Chem Lett. 2009 Jan 15;19(2):360-4. Epub 2008 Nov 24. PMID:19071018 [[Category: Pdbx_ordinal=, <PDBx:audit_author.]]
Page seeded by OCA on Wed Jan 7 20:12:56 2009
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- Homo sapiens
- Receptor protein-tyrosine kinase
- Single protein
- Alternative splicing
- Atp-binding
- Carbohydrate metabolism
- Cleavage on pair of basic residue
- Diabetes mellitus
- Disease mutation
- Glycoprotein
- Insulin
- Kinase
- Membrane
- Nucleotide-binding
- Phosphoprotein
- Polymorphism
- Receptor
- Transferase
- Transmembrane
- Tyrosine kinase
- Tyrosine-protein kinase
