3f8g | pdb_00003f8g
From Proteopedia
The X-ray structure of a dimeric variant of human pancreatic ribonuclease with high cytotoxic and antitumor activities
About this Structure
3F8G is a 2 chains structure of sequences from Homo sapiens. Full crystallographic information is available from OCA.
Reference
- Merlino A, Avella G, Di Gaetano S, Arciello A, Piccoli R, Mazzarella L, Sica F. Structural features for the mechanism of antitumor action of a dimeric human pancreatic ribonuclease variant. Protein Sci. 2009 Jan;18(1):50-7. PMID:19177350 doi:10.1002/pro.6
- Sica F, Di Fiore A, Merlino A, Mazzarella L. Structure and stability of the non-covalent swapped dimer of bovine seminal ribonuclease: an enzyme tailored to evade ribonuclease protein inhibitor. J Biol Chem. 2004 Aug 27;279(35):36753-60. Epub 2004 Jun 9. PMID:15192098 doi:https://dx.doi.org/10.1074/jbc.M405655200
- Merlino A, Ercole C, Picone D, Pizzo E, Mazzarella L, Sica F. The buried diversity of bovine seminal ribonuclease: shape and cytotoxicity of the swapped non-covalent form of the enzyme. J Mol Biol. 2008 Feb 15;376(2):427-37. Epub 2007 Nov 12. PMID:18164315 doi:https://dx.doi.org/10.1016/j.jmb.2007.11.008
- Piccoli R, Di Gaetano S, De Lorenzo C, Grauso M, Monaco C, Spalletti-Cernia D, Laccetti P, Cinatl J, Matousek J, D'Alessio G. A dimeric mutant of human pancreatic ribonuclease with selective cytotoxicity toward malignant cells. Proc Natl Acad Sci U S A. 1999 Jul 6;96(14):7768-73. PMID:10393896
- Di Gaetano S, D'alessio G, Piccoli R. Second generation antitumour human RNase: significance of its structural and functional features for the mechanism of antitumour action. Biochem J. 2001 Aug 15;358(Pt 1):241-7. PMID:11485573
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