2z8c | pdb_00002z8c
From Proteopedia
Phosphorylated insulin receptor tyrosine kinase in complex with (4-{[5-carbamoyl-4-(3-methylanilino)pyrimidin-2-yl]amino}phenyl)acetic acid
Disease
Known disease associated with this structure: Diabetes mellitus, insulin-resistant, with acanthosis nigricans OMIM:[147670], Hyperinsulinemic hypoglycemia, familial, 5 OMIM:[147670], Leprechaunism OMIM:[147670], Rabson-Mendenhall syndrome OMIM:[147670], Coronary artery disease, susceptibility to OMIM:[147545], Diabetes mellitus, noninsulin-dependent OMIM:[147545]
About this Structure
2Z8C is a 2 chains structure of sequences from Homo sapiens. Full crystallographic information is available from OCA.
Reference
- Katayama N, Orita M, Yamaguchi T, Hisamichi H, Kuromitsu S, Kurihara H, Sakashita H, Matsumoto Y, Fujita S, Niimi T. Identification of a key element for hydrogen-bonding patterns between protein kinases and their inhibitors. Proteins. 2008 Sep 2;73(4):795-801. PMID:18767165 doi:10.1002/prot.22207
Page seeded by OCA on Mon Feb 16 12:08:10 2009
Proteopedia Page Contributors and Editors (what is this?)
Categories:
- Pages with broken file links
- Homo sapiens
- Receptor protein-tyrosine kinase
- Katayama, N.
- Kurihara, H.
- Alternative splicing
- Atp-binding
- Carbohydrate metabolism
- Cleavage on pair of basic residue
- Diabetes mellitus
- Disease mutation
- Glycoprotein
- Kinase
- Membrane
- Nucleotide-binding
- Phosphorylation
- Polymorphism
- Receptor
- Transducer
- Transferase
- Transmembrane
- Tyrosine-protein kinase
