1y4f | pdb_00001y4f

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Template:STRUCTURE 1y4f

File:1y4f.png

T-To-T(High) quaternary transitions in human hemoglobin: betaW37A deoxy low-salt (10 test sets)

Template:ABSTRACT PUBMED 15835899

Disease

Known disease associated with this structure: Erythremias, beta- OMIM:[141900], Heinz body anemias, beta- OMIM:[141900], Hereditary persistence of fetal hemoglobin OMIM:[141900], Methemoglobinemias, beta- OMIM:[141900], Sickle cell anemia OMIM:[141900], Thalassemia-beta, dominant inclusion-body OMIM:[141900], Thalassemias, beta- OMIM:[141900]

About this Structure

1Y4F is a 4 chains structure of sequences from Homo sapiens. This structure supersedes the now removed PDB entry 1a0w. Full crystallographic information is available from OCA.

Reference

  1. Kavanaugh JS, Rogers PH, Arnone A. Crystallographic evidence for a new ensemble of ligand-induced allosteric transitions in hemoglobin: the T-to-T(high) quaternary transitions. Biochemistry. 2005 Apr 26;44(16):6101-21. PMID:15835899 doi:https://dx.doi.org/10.1021/bi047813a

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