1j3k | pdb_00001j3k

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Template:STRUCTURE 1j3k

File:1j3k.png

Quadruple mutant (N51I+C59R+S108N+I164L) Plasmodium falciparum dihydrofolate reductase-thymidylate synthase (PfDHFR-TS) complexed with WR99210, NADPH, and dUMP

Template:ABSTRACT PUBMED 12704428

About this Structure

1J3K is a 4 chains structure of sequences from Plasmodium falciparum. Full crystallographic information is available from OCA.

Reference

  1. Yuvaniyama J, Chitnumsub P, Kamchonwongpaisan S, Vanichtanankul J, Sirawaraporn W, Taylor P, Walkinshaw MD, Yuthavong Y. Insights into antifolate resistance from malarial DHFR-TS structures. Nat Struct Biol. 2003 May;10(5):357-65. PMID:12704428 doi:10.1038/nsb921

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