1rr8 | pdb_00001rr8

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File:1rr8.png

Template:STRUCTURE 1rr8

Structural Mechanisms of Camptothecin Resistance by Mutations in Human Topoisomerase I

Template:ABSTRACT PUBMED 15165849

Disease

Known disease associated with this structure: DNA topoisomerase I, camptothecin-resistant OMIM:[126420]

About this Structure

1RR8 is a 3 chains structure of sequences from Homo sapiens. Full crystallographic information is available from OCA.

Reference

  1. Chrencik JE, Staker BL, Burgin AB, Pourquier P, Pommier Y, Stewart L, Redinbo MR. Mechanisms of camptothecin resistance by human topoisomerase I mutations. J Mol Biol. 2004 Jun 11;339(4):773-84. PMID:15165849 doi:https://dx.doi.org/10.1016/j.jmb.2004.03.077

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