1y6e | pdb_00001y6e
Orthorhombic glutathione S-transferase of Schistosoma japonicum
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Overview
The crystal structure of the 26 kDa glutathione S-transferase from, Schistosoma japonicum (SjGST) was determined at 3 A resolution in the new, space group P2(1)2(1)2(1). The structure of orthorhombic SjGST reveals, unique features of the ligand-binding site and dimer interface when, compared with previously reported structures. SjGST is recognized as the, major detoxification enzyme of S. japonicum, a pathogenic helminth causing, schistosomiasis. As resistance against the established inhibitor of SjGST, praziquantel, has been reported these results might prove to be valuable, for the development of novel drugs.
About this Structure
1Y6E is a Single protein structure of sequence from Schistosoma japonicum. Active as Glutathione transferase, with EC number 2.5.1.18 Full crystallographic information is available from OCA.
Reference
X-ray structure of glutathione S-transferase from Schistosoma japonicum in a new crystal form reveals flexibility of the substrate-binding site., Rufer AC, Thiebach L, Baer K, Klein HW, Hennig M, Acta Crystallograph Sect F Struct Biol Cryst Commun. 2005 Mar 1;61(Pt, 3):263-5. Epub 2005 Feb 24. PMID:16511012
Page seeded by OCA on Wed Nov 21 06:36:02 2007
