3b2w | pdb_00003b2w

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File:3b2w.png

Template:STRUCTURE 3b2w

Crystal structure of pyrimidine amide 11 bound to Lck

Template:ABSTRACT PUBMED 18083554

Disease

Known disease associated with this structure: SCID due to LCK deficiency OMIM:[153390]

About this Structure

3B2W is a 1 chain structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Deak HL, Newcomb JR, Nunes JJ, Boucher C, Cheng AC, DiMauro EF, Epstein LF, Gallant P, Hodous BL, Huang X, Lee JH, Patel VF, Schneider S, Turci SM, Zhu X. N-(3-(phenylcarbamoyl)arylpyrimidine)-5-carboxamides as potent and selective inhibitors of Lck: structure, synthesis and SAR. Bioorg Med Chem Lett. 2008 Feb 1;18(3):1172-6. Epub 2007 Dec 5. PMID:18083554 doi:https://dx.doi.org/10.1016/j.bmcl.2007.11.123

Page seeded by OCA on Mon Feb 16 18:35:55 2009

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OCA

[1] Deak HL, Newcomb JR, Nunes JJ, Boucher C, Cheng AC, DiMauro EF, Epstein LF, Gallant P, Hodous BL, Huang X, Lee JH, Patel VF, Schneider S, Turci SM, Zhu X. N-(3-(phenylcarbamoyl)arylpyrimidine)-5-carboxamides as potent and selective inhibitors of Lck: structure, synthesis and SAR. Bioorg Med Chem Lett. 2008 Feb 1;18(3):1172-6. Epub 2007 Dec 5. PMID:18083554 doi:https://dx.doi.org/10.1016/j.bmcl.2007.11.123

3b2w | pdb_00003b2w

Contents

Crystal structure of pyrimidine amide 11 bound to Lck

Disease

About this Structure

Reference

Proteopedia Page Contributors and Editors (what is this?)

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