3bu5 | pdb_00003bu5
From Proteopedia
Crystal structure of the insulin receptor kinase in complex with IRS2 KRLB peptide and ATP
Template:ABSTRACT PUBMED 18278056
Disease
Known disease associated with this structure: Diabetes mellitus, insulin-resistant, with acanthosis nigricans OMIM:[147670], Hyperinsulinemic hypoglycemia, familial, 5 OMIM:[147670], Leprechaunism OMIM:[147670], Rabson-Mendenhall syndrome OMIM:[147670]
About this Structure
3BU5 is a 2 chains structure of sequences from Homo sapiens. Full crystallographic information is available from OCA.
Reference
- Wu J, Tseng YD, Xu CF, Neubert TA, White MF, Hubbard SR. Structural and biochemical characterization of the KRLB region in insulin receptor substrate-2. Nat Struct Mol Biol. 2008 Mar;15(3):251-8. Epub 2008 Feb 17. PMID:18278056 doi:10.1038/nsmb.1388
Page seeded by OCA on Mon Feb 16 18:49:45 2009
Proteopedia Page Contributors and Editors (what is this?)
Categories:
- Pages with broken file links
- Homo sapiens
- Receptor protein-tyrosine kinase
- Hubbard, S R.
- Wu, J.
- Alternative splicing
- Atp
- Atp-binding
- Carbohydrate metabolism
- Cleavage on pair of basic residue
- Diabetes mellitus
- Disease mutation
- Glycoprotein
- Insulin receptor
- Irk
- Irs2
- Kinase
- Krlb
- Membrane
- Nucleotide-binding
- Peptide
- Phosphoprotein
- Polymorphism
- Substrate
- Transducer
- Transferase
- Transmembrane
- Tyrosine-protein kinase
