1z7s | pdb_00001z7s
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The crystal structure of coxsackievirus A21
Overview
CVA21 and polioviruses both belong to the Enterovirus genus in the family, of Picornaviridae, whereas rhinoviruses form a distinct picornavirus, genus. Nevertheless, CVA21 and the major group of human rhinoviruses, recognize intercellular adhesion molecule-1 (ICAM-1) as their cellular, receptor, whereas polioviruses use poliovirus receptor. The crystal, structure of CVA21 has been determined to 3.2 A resolution. Its structure, has greater similarity to poliovirus structures than to other known, picornavirus structures. Cryo-electron microscopy (cryo-EM) was used to, determine an 8.0 A resolution structure of CVA21 complexed with an ICAM-1, variant, ICAM-1(Kilifi). The cryo-EM map was fitted with the crystal, structures of ICAM-1 and CVA21. Significant differences in the structure, of CVA21 with respect to the poliovirus structures account for the, inability of ICAM-1 to bind polioviruses. The interface between CVA21 and, ICAM-1 has shape and electrostatic complementarity with many residues, being conserved among those CVAs that bind ICAM-1.
About this Structure
1Z7S is a Protein complex structure of sequences from Human coxsackievirus a21 with CA, MYR and G as ligands. Full crystallographic information is available from OCA.
Reference
The crystal structure of coxsackievirus A21 and its interaction with ICAM-1., Xiao C, Bator-Kelly CM, Rieder E, Chipman PR, Craig A, Kuhn RJ, Wimmer E, Rossmann MG, Structure. 2005 Jul;13(7):1019-33. PMID:16004874
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