1s8o | pdb_00001s8o

File:1s8o.png

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1s8o, resolution 2.60Å (default scene)
Ligands:	P6G
Gene:	EPHX2 (Homo sapiens)
Activity:	Hydrolase, with EC number and 3.3.2.10 3.3.2.9 and 3.3.2.10
Related:	1vj5
Structural annotation: Resources: InterPro : Ipr011945, Ipr005834, Ipr006402, Ipr003089, Ipr005833, Ipr000639, Ipr000073 Pfam : PF00702, PF00561 SCOP : d1s8oa2, d1s8oa1 UniProt : P34913
Functional annotation: Cellular component: peroxisome soluble fraction cytosol cytoplasm Biological process: oxygen and reactive oxygen species metabolic process cellular calcium ion homeostasis inflammatory response response to toxin metabolic process positive regulation of vasodilation xenobiotic metabolic process drug metabolic process aromatic compound metabolic process aromatic compound catabolic process regulation of blood pressure Molecular function: magnesium ion binding catalytic activity epoxide hydrolase activity metal ion binding hydrolase activity protein homodimerization activity
Evolutionary conservation: Toggle Conservation Colors: Rows = identical sequences: Further Information: Caveats, Explanation, Complete Results at ConSurfDB
Resources:	FirstGlance, OCA, RCSB, PDBsum
Coordinates:	save as pdb, mmCIF, xml

Disease

Known disease associated with this structure: Hypercholesterolemia, familial, due to LDLR defect, modifier of OMIM:[132811]

About this Structure

1S8O is a 1 chain structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

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