2hyy | pdb_00002hyy

File:2hyy.png

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2hyy, resolution 2.40Å (default scene)
Ligands:	STI
Gene:	ABL1 (Homo sapiens)
Activity:	Non-specific protein-tyrosine kinase, with EC number 2.7.10.2
Related:	1iep, 1fpu
Structural annotation: Resources: InterPro : Ipr015015, Ipr000980, Ipr000719, Ipr011009, Ipr001245, Ipr008266, Ipr001452 Pfam : PF07714 UniProt : P00519
Functional annotation: Cellular component: cytoplasm nucleus cytoskeleton Biological process: actin cytoskeleton organization and biogenesis protein amino acid phosphorylation peptidyl-tyrosine phosphorylation intracellular signaling cascade mismatch repair DNA damage response, signal transduction resulting in induction of apoptosis S-phase-specific transcription in mitotic cell cycle regulation of transcription, DNA-dependent cell adhesion protein modification process Molecular function: ATP binding transferase activity protein-tyrosine kinase activity protein C-terminus binding nucleotide binding manganese ion binding magnesium ion binding protein kinase activity kinase activity protein binding DNA binding metal ion binding
Evolutionary conservation: Toggle Conservation Colors: Rows = identical sequences: Further Information: Caveats, Explanation, Complete Results at ConSurfDB
Resources:	FirstGlance, OCA, RCSB, PDBsum
Coordinates:	save as pdb, mmCIF, xml

Disease

Known disease associated with this structure: Leukemia, Philadelphia chromosome-positive, resistant to imatinib OMIM:[189980]

About this Structure

2HYY is a 4 chains structure of sequences from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Page seeded by OCA on Tue Feb 17 00:39:09 2009

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