3byu | pdb_00003byu
From Proteopedia
co-crystal structure of Lck and aminopyrimidine reverse amide 23
Template:ABSTRACT PUBMED 18321037
Disease
Known disease associated with this structure: SCID due to LCK deficiency OMIM:[153390]
About this Structure
3BYU is a 1 chain structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.
Reference
- DiMauro EF, Newcomb J, Nunes JJ, Bemis JE, Boucher C, Chai L, Chaffee SC, Deak HL, Epstein LF, Faust T, Gallant P, Gore A, Gu Y, Henkle B, Hsieh F, Huang X, Kim JL, Lee JH, Martin MW, McGowan DC, Metz D, Mohn D, Morgenstern KA, Oliveira-dos-Santos A, Patel VF, Powers D, Rose PE, Schneider S, Tomlinson SA, Tudor YY, Turci SM, Welcher AA, Zhao H, Zhu L, Zhu X. Structure-guided design of aminopyrimidine amides as potent, selective inhibitors of lymphocyte specific kinase: synthesis, structure-activity relationships, and inhibition of in vivo T cell activation. J Med Chem. 2008 Mar 27;51(6):1681-94. Epub 2008 Mar 6. PMID:18321037 doi:10.1021/jm7010996
Page seeded by OCA on Tue Feb 17 02:12:21 2009
Proteopedia Page Contributors and Editors (what is this?)
Categories:
- Pages with broken file links
- Homo sapiens
- Non-specific protein-tyrosine kinase
- Huang, X.
- Alternative splicing
- Atp-binding
- Chromosomal rearrangement
- Cytoplasm
- Disease mutation
- Host-virus interaction
- Kinase domain
- Lck
- Lipoprotein
- Membrane
- Myristate
- Nucleotide-binding
- Palmitate
- Phosphoprotein
- Proto-oncogene
- Sh2 domain
- Sh3 domain
- Transferase
- Tyrosine-protein kinase
