2zn7 | pdb_00002zn7

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Template:STRUCTURE 2zn7

File:2zn7.png

CRYSTAL STRUCTURES OF PTP1B-Inhibitor Complexes

Disease

Known disease associated with this structure: Insulin resistance, susceptibility to OMIM:[176885]

About this Structure

2ZN7 is a 1 chain structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

  1. Wan ZK, Lee J, Hotchandani R, Moretto A, Binnun E, Wilson DP, Kirincich SJ, Follows BC, Ipek M, Xu W, Joseph-McCarthy D, Zhang YL, Tam M, Erbe DV, Tobin JF, Li W, Tam SY, Mansour TS, Wu J. Structure-based optimization of protein tyrosine phosphatase-1 B inhibitors: capturing interactions with arginine 24. ChemMedChem. 2008 Oct;3(10):1525-9. PMID:18798205 doi:10.1002/cmdc.200800188

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