3bw5 | pdb_00003bw5

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File:3bw5.png

Template:STRUCTURE 3bw5

Crystal structure of a mutant of human protein kinase CK2alpha with altered cosubstrate specificity

Template:ABSTRACT PUBMED 18291315

About this Structure

3BW5 is a 1 chain structure of sequence from Homo sapiens. This structure supersedes the now removed PDB entry 1ymi. Full crystallographic information is available from OCA.

Reference

  1. Raaf J, Brunstein E, Issinger OG, Niefind K. The CK2 alpha/CK2 beta interface of human protein kinase CK2 harbors a binding pocket for small molecules. Chem Biol. 2008 Feb;15(2):111-7. PMID:18291315 doi:https://dx.doi.org/10.1016/j.chembiol.2007.12.012
  2. Yde CW, Ermakova I, Issinger OG, Niefind K. Inclining the purine base binding plane in protein kinase CK2 by exchanging the flanking side-chains generates a preference for ATP as a cosubstrate. J Mol Biol. 2005 Mar 25;347(2):399-414. Epub 2005 Jan 18. PMID:15740749 doi:https://dx.doi.org/10.1016/j.jmb.2005.01.003

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