2aei | pdb_00002aei
From Proteopedia
Crystal structure of a ternary complex of factor VIIa/tissue factor and 2-[[6-[3-(aminoiminomethyl)phenoxy]-3,5-difluro-4-[(1-methyl-3-phenylpropyl)amino]-2-pyridinyl]oxy]-benzoic acid
Template:ABSTRACT PUBMED 16125385
Disease
Known disease associated with this structure: Factor VII deficiency OMIM:[227500], Myocardial infarction, decreased susceptibility to OMIM:[227500]
About this Structure
2AEI is a 3 chains structure of sequences from Homo sapiens. Full crystallographic information is available from OCA.
Reference
- Kohrt JT, Filipski KJ, Cody WL, Cai C, Dudley DA, Van Huis CA, Willardsen JA, Rapundalo ST, Saiya-Cork K, Leadley RJ, Narasimhan L, Zhang E, Whitlow M, Adler M, McLean K, Chou YL, McKnight C, Arnaiz DO, Shaw KJ, Light DR, Edmunds JJ. The discovery of fluoropyridine-based inhibitors of the Factor VIIa/TF complex. Bioorg Med Chem Lett. 2005 Nov 1;15(21):4752-6. PMID:16125385 doi:10.1016/j.bmcl.2005.07.059
Page seeded by OCA on Tue Feb 17 07:48:29 2009
