2bct | pdb_00002bct
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THE ARMADILLO REPEAT REGION FROM MURINE BETA-CATENIN
Overview
Beta-catenin is essential for cadherin-based cell adhesion and, Wnt/Wingless growth factor signaling. In these roles, it binds to, cadherins, Tcf-family transcription factors, and the tumor suppressor gene, product Adenomatous Polyposis Coli (APC). A core region of beta-catenin, composed of 12 copies of a 42 amino acid sequence motif known as an, armadillo repeat, mediates these interactions. The three-dimensional, structure of a protease-resistant fragment of beta-catenin containing the, armadillo repeat region has been determined. The 12 repeats form a, superhelix of helices that features a long, positively charged groove., Although unrelated in sequence, the beta-catenin binding regions of, cadherins, Tcfs, and APC are acidic and are proposed to interact with this, groove.
About this Structure
2BCT is a Single protein structure of sequence from Mus musculus. Full crystallographic information is available from OCA.
Reference
Three-dimensional structure of the armadillo repeat region of beta-catenin., Huber AH, Nelson WJ, Weis WI, Cell. 1997 Sep 5;90(5):871-82. PMID:9298899
Page seeded by OCA on Wed Nov 21 08:43:56 2007
