3c6k | pdb_00003c6k

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File:3c6k.png

Template:STRUCTURE 3c6k

Crystal structure of human spermine synthase in complex with spermidine and 5-methylthioadenosine

Template:ABSTRACT PUBMED 18367445

Disease

Known disease associated with this structure: Mental retardation, X-linked, Snyder-Robinson type OMIM:[300105], Smith-Magenis syndrome OMIM:[607642]

About this Structure

3C6K is a 4 chains structure of sequences from Homo sapiens. This structure supersedes the now removed PDB entry 2qfm. Full crystallographic information is available from OCA.

Reference

  1. Wu H, Min J, Zeng H, McCloskey DE, Ikeguchi Y, Loppnau P, Michael AJ, Pegg AE, Plotnikov AN. Crystal structure of human spermine synthase: implications of substrate binding and catalytic mechanism. J Biol Chem. 2008 Jun 6;283(23):16135-46. Epub 2008 Mar 26. PMID:18367445 doi:https://dx.doi.org/10.1074/jbc.M710323200

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