2itz | pdb_00002itz
From Proteopedia
CRYSTAL STRUCTURE OF EGFR KINASE DOMAIN L858R MUTATION IN COMPLEX WITH IRESSA
About this Structure
2ITZ is a 1 chain structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.
Reference
- Yun CH, Boggon TJ, Li Y, Woo MS, Greulich H, Meyerson M, Eck MJ. Structures of lung cancer-derived EGFR mutants and inhibitor complexes: mechanism of activation and insights into differential inhibitor sensitivity. Cancer Cell. 2007 Mar;11(3):217-27. PMID:17349580 doi:https://dx.doi.org/10.1016/j.ccr.2006.12.017
Page seeded by OCA on Tue Feb 17 11:20:35 2009
Proteopedia Page Contributors and Editors (what is this?)
Categories:
- Pages with broken file links
- Homo sapiens
- Receptor protein-tyrosine kinase
- Boggon, T J.
- Eck, M J.
- Greulich, H.
- Li, Y.
- Meyerson, M.
- Woo, S.
- Yun, C H.
- Alternative splicing
- Anti-oncogene
- Atp-binding
- Cell cycle
- Disease mutation
- Egfr
- Epidermal growth factor
- Gefitinib
- Glycoprotein
- Iressa
- L858r
- Membrane
- Nucleotide-binding
- Phosphorylation
- Polymorphism
- Receptor
- Transferase
- Transmembrane
- Tyrosine-protein kinase
- Zd1839
