3c2i | pdb_00003c2i
From Proteopedia
The Crystal Structure of Methyl-CpG Binding Domain of Human MeCP2 in Complex with a Methylated DNA Sequence from BDNF
Template:ABSTRACT PUBMED 18313390
Disease
Known disease associated with this structure: Angelman syndrome OMIM:[300005], Encephalopathy, neonatal severe OMIM:[300005], Mental retardation, X-linked, Lubs type OMIM:[300005], Mental retardation, X-linked, syndromic 13 OMIM:[300005], Rett syndrome OMIM:[300005], Rett syndrome, preserved speech variant OMIM:[300005], Autism, susceptibility to, X-linked-3 OMIM:[300005]
About this Structure
3C2I is a 3 chains structure of sequences from Homo sapiens. Full crystallographic information is available from OCA.
Reference
- Ho KL, McNae IW, Schmiedeberg L, Klose RJ, Bird AP, Walkinshaw MD. MeCP2 binding to DNA depends upon hydration at methyl-CpG. Mol Cell. 2008 Feb 29;29(4):525-31. PMID:18313390 doi:10.1016/j.molcel.2007.12.028
Page seeded by OCA on Tue Feb 17 11:31:25 2009
Proteopedia Page Contributors and Editors (what is this?)
Categories:
- Pages with broken file links
- Homo sapiens
- Bird, A P.
- Ho, K L.
- Klose, R J.
- McNae, I W.
- Schmiedeberg, L.
- Walkinshaw, M D.
- Alternative splicing
- Asx-st-motif
- Chromosomal rearrangement
- Disease mutation
- Dna-binding
- Nucleus
- Phosphoprotein
- Polymorphism
- Protein-methylated dna complex
- Repressor
- Transcription regulator
- Water mediated recognition
