2p4j | pdb_00002p4j

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File:2p4j.png

Template:STRUCTURE 2p4j

Crystal structure of beta-secretase bond to an inhibitor with Isophthalamide Derivatives at P2-P3

Template:ABSTRACT PUBMED 17432843

About this Structure

2P4J is a 4 chains structure of sequences from Homo sapiens. Full crystallographic information is available from OCA.

Reference

  1. Ghosh AK, Kumaragurubaran N, Hong L, Kulkarni SS, Xu X, Chang W, Weerasena V, Turner R, Koelsch G, Bilcer G, Tang J. Design, synthesis, and X-ray structure of potent memapsin 2 (beta-secretase) inhibitors with isophthalamide derivatives as the P2-P3-ligands. J Med Chem. 2007 May 17;50(10):2399-407. Epub 2007 Apr 14. PMID:17432843 doi:10.1021/jm061338s

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