1t4v | pdb_00001t4v
From Proteopedia
Crystal Structure Analysis of a novel Oxyguanidine bound to Thrombin
Template:ABSTRACT PUBMED 15203151
Disease
Known disease associated with this structure: Dysprothrombinemia OMIM:[176930], Hyperprothrombinemia OMIM:[176930], Hypoprothrombinemia OMIM:[176930]
About this Structure
1T4V is a 3 chains structure of sequences from Hirudo medicinalis and Homo sapiens. Full crystallographic information is available from OCA.
Reference
- Lu T, Markotan T, Coppo F, Tomczuk B, Crysler C, Eisennagel S, Spurlino J, Gremminger L, Soll RM, Giardino EC, Bone R. Oxyguanidines. Part 2: Discovery of a novel orally active thrombin inhibitor through structure-based drug design and parallel synthesis. Bioorg Med Chem Lett. 2004 Jul 16;14(14):3727-31. PMID:15203151 doi:https://dx.doi.org/10.1016/j.bmcl.2004.05.002
Page seeded by OCA on Tue Feb 17 18:36:48 2009
