1tp0 | pdb_00001tp0

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File:1tp0.png

Template:STRUCTURE 1tp0

Triple mutation in interleukin 1 beta cavity:replacement of phenylalanines with tryptophan.

Template:ABSTRACT PUBMED 15663946

Disease

Known disease associated with this structure: Gastric cancer risk after H. pylori infection OMIM:[147720]

About this Structure

1TP0 is a 1 chain structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

  1. Adamek DH, Guerrero L, Blaber M, Caspar DL. Structural and energetic consequences of mutations in a solvated hydrophobic cavity. J Mol Biol. 2005 Feb 11;346(1):307-18. Epub 2004 Dec 24. PMID:15663946 doi:10.1016/j.jmb.2004.11.046

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