1seu | pdb_00001seu

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File:1seu.png

Template:STRUCTURE 1seu

Human DNA Topoisomerase I (70 Kda) In Complex With The Indolocarbazole SA315F and Covalent Complex With A 22 Base Pair DNA Duplex

Template:ABSTRACT PUBMED 15801827

Disease

Known disease associated with this structure: DNA topoisomerase I, camptothecin-resistant OMIM:[126420]

About this Structure

1SEU is a 4 chains structure of sequences from Homo sapiens. Full crystallographic information is available from OCA.

Reference

  1. Staker BL, Feese MD, Cushman M, Pommier Y, Zembower D, Stewart L, Burgin AB. Structures of three classes of anticancer agents bound to the human topoisomerase I-DNA covalent complex. J Med Chem. 2005 Apr 7;48(7):2336-45. PMID:15801827 doi:10.1021/jm049146p

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