2g02 | pdb_00002g02
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Nisin cyclase
Overview
Nisin is a posttranslationally modified antimicrobial peptide that is, widely used as a food preservative. It contains five cyclic thioethers of, varying sizes that are installed by a single enzyme, NisC. Reported here, are the in vitro reconstitution of the cyclization process and the x-ray, crystal structure of the NisC enzyme. The structure reveals similarities, in fold and substrate activation with mammalian farnesyl transferases, suggesting that human homologs of NisC posttranslationally modify a, cysteine of a protein substrate.
About this Structure
2G02 is a Single protein structure of sequence from Lactococcus lactis subsp. lactis with ZN as ligand. Full crystallographic information is available from OCA.
Reference
Structure and mechanism of the lantibiotic cyclase involved in nisin biosynthesis., Li B, Yu JP, Brunzelle JS, Moll GN, van der Donk WA, Nair SK, Science. 2006 Mar 10;311(5766):1464-7. PMID:16527981
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