2r4f | pdb_00002r4f
From Proteopedia
Substituted Pyrazoles as Hepatselective HMG-COA reductase inhibitors
Disease
Known disease associated with this structure: Statins, attenuated cholesterol lowering by OMIM:[142910]
About this Structure
2R4F is a 4 chains structure of sequences from Homo sapiens. Full crystallographic information is available from OCA.
Reference
- Pfefferkorn JA, Choi C, Larsen SD, Auerbach B, Hutchings R, Park W, Askew V, Dillon L, Hanselman JC, Lin Z, Lu GH, Robertson A, Sekerke C, Harris MS, Pavlovsky A, Bainbridge G, Caspers N, Kowala M, Tait BD. Substituted pyrazoles as hepatoselective HMG-CoA reductase inhibitors: discovery of (3R,5R)-7-[2-(4-fluoro-phenyl)-4-isopropyl-5-(4-methyl-benzylcarbamoyl)-2H -pyrazol-3-yl]-3,5-dihydroxyheptanoic acid (PF-3052334) as a candidate for the treatment of hypercholesterolemia. J Med Chem. 2008 Jan 10;51(1):31-45. Epub 2007 Dec 12. PMID:18072721 doi:10.1021/jm070849r
Page seeded by OCA on Tue Feb 17 23:32:17 2009
Proteopedia Page Contributors and Editors (what is this?)
Categories:
- Pages with broken file links
- Homo sapiens
- Finzel, B C.
- Harris, M S.
- Pavlovsky, A.
- Pfefferkorn, J A.
- Alternative splicing
- Biocynthesis
- Cholesterol
- Cholesterol biosynthesis
- Endoplasmic reticulum
- Glycoprotein
- Hmg-coa
- Lipid synthesis
- Membrane
- Nadph
- Oxidoreductase
- Peroxisome
- Polymorphism
- Statin
- Steroid biosynthesis
- Sterol biosynthesis
- Transmembrane
