2zm3 | pdb_00002zm3
From Proteopedia
Complex Structure of Insulin-like Growth Factor Receptor and Isoquinolinedione Inhibitor
Template:ABSTRACT PUBMED 18501599
Disease
Known disease associated with this structure: Insulin-like growth factor I, resistance to OMIM:[147370]
About this Structure
2ZM3 is a 4 chains structure of sequences from Homo sapiens. Full crystallographic information is available from OCA.
Reference
- Mayer SC, Banker AL, Boschelli F, Di L, Johnson M, Kenny CH, Krishnamurthy G, Kutterer K, Moy F, Petusky S, Ravi M, Tkach D, Tsou HR, Xu W. Lead identification to generate isoquinolinedione inhibitors of insulin-like growth factor receptor (IGF-1R) for potential use in cancer treatment. Bioorg Med Chem Lett. 2008 Jun 15;18(12):3641-5. Epub 2008 Apr 25. PMID:18501599 doi:10.1016/j.bmcl.2008.04.044
Page seeded by OCA on Wed Feb 18 01:41:09 2009
Proteopedia Page Contributors and Editors (what is this?)
Categories:
- Pages with broken file links
- Homo sapiens
- Receptor protein-tyrosine kinase
- Boschelli, F.
- Dwyer, B.
- Johnson, M.
- Mayer, S C.
- Xu, W.
- Atp-binding
- Cleavage on pair of basic residue
- Disease mutation
- Glycoprotein
- Igfr
- Membrane
- Nucleotide-binding
- Phosphoprotein
- Polymorphism
- Protein-inhibitor complex
- Receptor
- Transferase
- Transmembrane
- Tyrosine kinase
- Tyrosine-protein kinase
