2qtl | pdb_00002qtl

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Template:STRUCTURE 2qtl

File:2qtl.png

Crystal Structure of the FAD-containing FNR-like Module of Human Methionine Synthase Reductase

Template:ABSTRACT PUBMED 17892308

Disease

Known disease associated with this structure: Homocystinuria-megaloblastic anemia, cbl E type OMIM:[602568], Neural tube defects, folate-sensitive, susceptibility to OMIM:[602568]

About this Structure

2QTL is a 1 chain structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

  1. Wolthers KR, Lou X, Toogood HS, Leys D, Scrutton NS. Mechanism of coenzyme binding to human methionine synthase reductase revealed through the crystal structure of the FNR-like module and isothermal titration calorimetry. Biochemistry. 2007 Oct 23;46(42):11833-44. Epub 2007 Sep 25. PMID:17892308 doi:10.1021/bi701209p

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