Sandbox7

This sandbox is in use until June 1, 2009 for UMass Chemistry 490a. Others please do not edit this page. Thanks! ' Abraham Khorasani

The potassium channel is an integral membrane protein consisting of four identical subunits. Because it is located in the membrane, its hydrophobic groups are located on the outside of the structure, where they interact with the lipids inside the membrane. The interior of the channel, meanwhile, is hydrophobic with polar groups to interact with potassium cations. Hydrophobic residues are located on the outside of the alpha helices.

Adam Nelson

When you exam the protein with no helices visible, it is clear that the protein binds ligand and has a four subunits structure similar to hemoglobin. Information from 1bl8.

spinqualitylabelsall models Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D load='1bl8' size='350' frame='false' scene=
1bl8, resolution 3.20Å (default scene)
Ligands:	K
Structural annotation: Resources: CATH : 1Bl8A00, 1Bl8B00, 1Bl8C00, 1Bl8D00 InterPro : Ipr003091, Ipr013099 Pfam : PF07885 SCOP : d1bl8a_, d1bl8b_, d1bl8c_, d1bl8d_ UniProt : P0A334
Functional annotation: Cellular component: integral to membrane membrane voltage-gated potassium channel complex Biological process: transport ion transport potassium ion transport Molecular function: ion channel activity voltage-gated potassium channel activity voltage-gated ion channel activity
Evolutionary conservation: Toggle Conservation Colors: Rows = identical sequences: Further Information: Caveats, Explanation, Complete Results at ConSurfDB
Resources:	FirstGlance, OCA, RCSB, PDBsum
Coordinates:	save as pdb, mmCIF, xml