Sandbox22
This sandbox is in use until June 1, 2009 for UMass Chemistry 490a. Others please do not edit this page. Thanks!
Glucokinase
--Student 07:51, 4 March 2009 (IST)Niva Ran and Tinuke Adeyemi
=General Information
Glucokinase is a monomeric enzyme that displays a low affinity for glucose and a sigmoidal saturation curve for its substrate, two properties that are important for its playing the role of a glucose sensor in pancreas and liver. Its structures also revealed an allosteric site through which small molecules may modulate the kinetic properties of the enzyme. This finding provided the mechanistic basis for activation of glucokinase as a potential therapeutic approach for treating type 2 diabetes mellitus.
Structure
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| 3cin, resolution 1.70Å (default scene) | |||||||||||||
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| Ligands: | CL, MG, NAD | ||||||||||||
| Gene: | TM1419, TM_1419 (Thermotoga maritima MSB8) | ||||||||||||
| Activity: | Inositol-3-phosphate synthase, with EC number 5.5.1.4 | ||||||||||||
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| Resources: | FirstGlance, OCA, RCSB, PDBsum, TOPSAN | ||||||||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||||||||
