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Glucokinase

Glucokinase is a monomeric enzyme that displays a low affinity for glucose and a sigmoidal saturation curve for its substrate, two properties that are important for its playing the role of a glucose sensor in pancreas and liver. Its structures also revealed an allosteric site through which small molecules may modulate the kinetic properties of the enzyme. This finding provided the mechanistic basis for activation of glucokinase as a potential therapeutic approach for treating type 2 diabetes mellitus.

Structure

spinqualitylabelsall models Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D load='1v4s' size='350' frame='false' scene=
1v4s, resolution 2.30Å (default scene)
Ligands:	GLC, MRK, NA
Activity:	Hexokinase, with EC number 2.7.1.1
Related:	1v4t
Structural annotation: Resources: InterPro : Ipr001312 Pfam : PF00349, PF03727 SCOP : d1v4sa2, d1v4sa1 UniProt : P35557
Functional annotation: Biological process: glucose homeostasis detection of glucose positive regulation of glycogen biosynthetic process glucose metabolic process glycolysis negative regulation of gluconeogenesis positive regulation of insulin secretion Molecular function: glucokinase activity kinase activity nucleotide binding hexokinase activity transferase activity ATP binding protein binding glucose binding
Evolutionary conservation: Toggle Conservation Colors: Rows = identical sequences: Further Information: Caveats, Explanation, Complete Results at ConSurfDB
Resources:	FirstGlance, OCA, RCSB, PDBsum
Coordinates:	save as pdb, mmCIF, xml

The glucokinase has 18 alpha helices (unless we counted wrong), 13 beta sheets (this one is for sure), and 3 ligands: a sodium ion, 2 amino-4-fluoro-5-[(1-methyl-1h-amidazol-2-yl)sulfanyl]-n-(1,3-thiazol-2-yl)benzamide or MRK in short, and last a sugar (alpha-d-glucose) or simply GLC.

Reference

https://www.proteopedia.org/wiki/index.php/1v4s

--Tinuke (Abike etc. etc. etc.) Adeyemi and Niva Ran

and Matt Joseph Rozin (because he's so nice to us....)