3b2u | pdb_00003b2u
From Proteopedia
Crystal structure of isolated domain III of the extracellular region of the epidermal growth factor receptor in complex with the Fab fragment of IMC-11F8
Disease
Known disease associated with this structure: Adenocarcinoma of lung, response to tyrosine kinase inhibitor in OMIM:[131550], Nonsmall cell lung cancer, response to tyrosine kinase inhibitor in OMIM:[131550], Nonsmall cell lung cancer, susceptibility to OMIM:[131550]
About this Structure
3B2U is a 24 chains structure of sequences from Homo sapiens. Full crystallographic information is available from OCA.
Reference
- Li S, Kussie P, Ferguson KM. Structural basis for EGF receptor inhibition by the therapeutic antibody IMC-11F8. Structure. 2008 Feb;16(2):216-27. PMID:18275813 doi:10.1016/j.str.2007.11.009
Page seeded by OCA on Sun Mar 22 11:00:22 2009
Proteopedia Page Contributors and Editors (what is this?)
Categories:
- Pages with broken file links
- Homo sapiens
- Receptor protein-tyrosine kinase
- Ferguson, K M.
- Kussie, P.
- Li, S.
- Alternative splicing
- Anti-oncogene
- Antigen:antibody complex
- Antitumor
- Atp-binding
- Cell cycle
- Cell surface receptor
- Disease mutation
- Drug
- Fab fragment
- Glycoprotein
- Immune system/transferase complex
- Kinase
- Membrane
- Nucleotide-binding
- Phosphoprotein
- Polymorphism
- Secreted
- Transferase
- Transmembrane
- Tyrosine-protein kinase
- Ubl conjugation
